2020 is commencing as a remarkable 12 months for weed. After legalization in Illinois and thousands of humans getting their weed-associated crook statistics deleted, Italian scientists just stated they determined a brand new natural cannabinoid that is 30 instances stronger than THC.
There‘s a motive why we name hashish a miracle plant. Besides the 2 first-rate-recognised cannabinoids THC and CBD there are around 500 other chemicals inside the cannabis plant. Italian researchers studying a medical hashish strain grown exclusively by the Italian military determined unusual chemical signatures and decided to dig deeper.
After taking a more in-depth look, they succeeded in identifying and separating formerly unknown cannabinoids, THCP (tetrahydrocannabiphorol) and CBDP (cannabidiphorol).
The “new” cannabinoid THCP is nearly same to THC, which we all understand and love, but has a few greater carbon atoms on the molecule’s tail stop. Those more atoms appear to be what makes THCP so much stronger than THC.
THC, CBD, and all other cannabinoids paintings by binding to 2 receptors in our body known as CB1 and CB2 receptors. Through those receptors, they interact with our endocannabinoid gadget to alter all sorts of bodily capabilities, heal us, or get us high.
According to the look at, THCP binds 30 times more potent to the CB1 and CB2 receptors than THC. The researchers examined THCP on mice and discovered that a tiny dose of 5mg/kg changed into enough to intoxicate them.
“Our in vitro experiments proved that THCP has a excessive affinity for CB1 receptors, about 30 instances better than that pronounced for THC inside the literature,” Cinzia Citti, one of the crew’s researchers instructed Medical Cannabis Network.
What does this imply for cannabis?
The study’s authors think that THCP might be the cause that there’s a lot variety in phrases of consequences from one of a kind lines of weed, which could assist us get a higher knowledge of the way cannabis impacts humans.
“The presence of this new phytocannabinoid could account for the pharmacological homes of some hashish types hard to give an explanation for through the presence of the sole THC,” Citti said.
“The hassle is that nobody has ever looked for those two compounds in hashish. Maybe, the identity of THCP in other varieties may want to account for inexplicable consequences now not ascribable entirely to THC.”
Citti additionally pressured that loads extra research is needed to get a better knowledge of THCP and CBDP, as well as how they have interaction with our bodies and different cannabinoids.
“Everything beyond our initial experiments represents handiest a hypothesis,” she stated. “Our major message is the significance to evaluate the exact chemical profile of a cannabis-based medication and understand whenever the precise concentration of all active principles, in any other case it might be not reasonable to take into account cannabis a remedy.”
Let’s desire this new discovery will lead to greater investment for cannabis research and greater amazing discoveries in the destiny.