In a large take a look at of 26,000 people, the hippocampus “choked” on marijuana. (The hippocampus is the brain’s reminiscence and learning middle.) Marijuana lowered blood go with the flow to levels unseen in every other institution. Find out why this strongly indicates better vulnerability to Alzheimer’s.
As the U.S. Races to legalize marijuana for medicinal and recreational use, a large scale mind imaging study offers motive for caution. Published in the Journal of Alzheimer’s Disease, researchers the use of single photon emission computed tomography (SPECT), an advanced imaging examine that evaluates blood waft and pastime patterns, confirmed abnormally low blood waft in actually every place of the brain, in nearly 1,000 marijuana customers compared to wholesome controls.
Marijuana, Alzheimer’s & the Hippocampus
The marijuana users’ low blood flow patterns included areas known to be affected by Alzheimer’s pathology such as the hippocampus.
All data were obtained for analysis from a large multi-site database, involving 26,268 patients who came for evaluation of complex, treatment resistant issues to one of nine outpatient neuropsychiatric clinics across the United States (Newport Beach, Costa Mesa, Fairfield, and Brisbane, CA, Tacoma and Bellevue, WA, Reston, VA, Atlanta, GA and New York, NY) between 1995-2015. Of these, 982 current or former marijuana users had brain SPECT at rest and during a mental concentration task compared to almost 100 healthy controls. Predictive analytics with discriminant analysis was done to determine if brain SPECT regions can distinguish marijuana user brains from controls brain.
Low Blood Flow
Low blood flow in the hippocampus in marijuana users reliably distinguished marijuana users from controls. The right hippocampus during a concentration task was the single most predictive region in distinguishing marijuana users from their normal counterparts. Marijuana use is thought to interfere with memory formation by inhibiting activity in this part of the brain.
According to one of the co-authors on the study Elisabeth Jorandby, M.D., “As a physician who routinely sees marijuana users, what struck me was not only the global reduction in blood flow in the marijuana users brains, but that the hippocampus was the most affected region due to its role in memory and Alzheimer’s disease.”
May Be Harbingers of Brain Damage
She continued, “Our research has proven that marijuana users have lower cerebral blood flow than non-users. Second, the most predictive region separating these two groups is low blood flow in the hippocampus on concentration brain SPECT imaging. This work suggests that marijuana use has damaging influences in the brain – particularly regions important in memory and learning and known to be affected by Alzheimer’s.”
Dr. George Perry, Editor in Chief of the Journal of Alzheimer’s Disease said, “Open use of marijuana, through legalization, will reveal the wide range of marijuana’s benefits and threats to human health. This study indicates troubling effects on the hippocampus that may be the harbingers of brain damage.”