Worldwide, breast cancer comprises 10.4% of all cancer incidence among women, making it the second most common type of non-skin cancer (after lung cancer) and the fifth most common cause of cancer death.
Research has shown that cannabis breast cancer treatment can be effective in treating breast cancer and are particularly effective against aggressive forms of the condition.
An in vitro study of the effect of cannabis breast cancer treatment on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. Cannabis breast cancer treatment inhibited the survival of both oestrogen receptor–positive and oestrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic mammary cells.
Other studies have also shown the antitumor effect of cannabinoids (CBD and THC) in preclinical models of breast cancer. Cannabis breast cancer treatments involving Cannabidiolic acid (CBDA) which is an inhibitor of MDA-MB-231 breast cancer cell migration (stops them spreading) and have been reported to possess anti-proliferative effects (stops growth or their ability to multiply) on cancer cells.
CBD is the second-most abundant cannabinoid within marijuana, but does not cause the psychotropic high of THC. Although some highly successful treatments have been developed, certain breast tumours are resistant to conventional therapies and a considerable number of them relapse.
Experimental evidence accumulated during the last decade supports the fact that cannabis breast cancer treatment with cannabinoids and their derivatives, exhibit anti-cancer properties.
Dr. Pierre Desprez completed his Ph.D. at the University of Lyon in France, and worked as a postdoctoral fellow in the laboratories of Drs. Judith Campisi and Mina Bissell
Initially at the Lawrence Berkeley National Laboratory on mammary gland dev elopment, breast cancer and cellular senescence in particular. Desprez reports:
“We started by researching breast cancer, but now we’ve found that cannabidiol cannabis breast cancer treatment also works with many other kinds of aggressive cancers; brain, prostate, any kind in which these high levels of ID-1 are present”.
Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells (through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase).
In the United States alone, breast cancer affects hundreds of thousands of women and many men every year. Some non-invasive forms of the disease are relatively treatable, but many types are far more aggressive.
CANNABIS TREATMENT FOR BREAST CANCER
Despite ever increasing research and new drug trials certain breast tumours continue to be resistant to conventional treatments.
One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumours. During this 2-year study, groups of mice and rats were given various doses of THC by gavage.
A dose-related decrease in the incidence of hepatic adenoma tumours and hepatocellular carcinoma (HCC) was observed in the mice. Decreased incidences of benign tumours (polyps and adenomas) in other organs (mammary gland, uterus, pituitary, testis, and pancreas) were also noted in the rats.
In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo . In addition, other tumours have been shown to be sensitive to cannabinoid-induced growth inhibition.
Breast cancer is comprised of tumours that are distinct in their molecular profiles and these are categorized into five main intrinsic or molecular sub types that are based on the genes a cancer expresses:
Luminal A breast cancer is hormone-receptor positive (oestrogen-receptor and/or progesterone-receptor positive), HER2 negative, and has low levels of the protein Ki-67, which helps control how fast cancer cells grow. Luminal A cancers are low-grade, tend to grow slowly and have the best prognosis.
This breast cancer is hormone-receptor positive (oestrogen-receptor and/or progesterone-receptor positive), and either HER2 positive or HER2 negativewith high levels of Ki-67. Luminal B cancers generally grow slightly faster than luminal A cancers and their prognosis is slightly worse.
This breast cancer is hormone-receptor negative (oestrogen-receptor and progesterone-receptor negative) and HER2 negative. This type of cancer is more common in women with BRCA1 gene mutations. Researchers aren’t sure why, but this type of cancer also is more common among younger and African-American women.
A recent study indicated that a proportion of these cells exhibit cannabinoid receptors, making cannabis breast cancer treatment one of the most suitable potential targeted treatments, particularly for Triple-Negative Breast Cancer. A further study reported in Molecular Oncology reported in 2015:
“The anti-tumour role and mechanisms of Cannabidiol (CBD), a non-psychotropic cannabinoid compound, are not well studied especially in triple-negative breast cancer (TNBC). In the present study, we analysed CBD’s anti-tumorigenic activity against highly aggressive breast cancer cell lines including TNBC subtype. We show here for the first time-that CBD significantly inhibits epidermal growth factor (EGF)-induced proliferation and chemotaxis of breast cancer cells.”
This breast cancer is hormone-receptor negative (oestrogen-receptor and progesterone-receptor negative) and HER2 positive. HER2-enriched cancers tend to grow faster than luminal cancers and can have a worse prognosis, but they are often successfully treated with targeted therapies aimed at the HER2 protein, such as Herceptin (chemical name: trastuzumab), Perjeta (chemical name: pertuzumab), Tykerb (chemical name: lapatinib), and Kadcyla (chemical name: T-DM1 or ado-trastuzumab emtansine).
This breast cancer is similar to luminal A disease: hormone-receptor positive (oestrogen-receptor and/or progesterone-receptor positive), HER2 negative, and has low levels of the protein Ki-67, which helps control how fast cancer cells grow. Still, while normal-like breast cancer has a good prognosis, its prognosis is slightly worse than luminal A cancer’s prognosis.
Research suggests that cannabinoids and phytocannabinoids (mainly THC and CBD) may be useful in treating all 5 subtypes of breast cancer, with the strongest evidence of therapeutic potential pointing to treatment of HER2-positive and triple-negative breast tumours.
The therapeutic potential of cannabis breast cancer treatment is particularly important for patients with triple-negative breast cancer, as there is no standard therapy that currently exists and prognosis for this group of patients is poor.
Senior Scientist Dr. Sean McAllister, PhD, and colleague Pierre Desprez, PhD, discovered that the cannabinoid, cannabidiol (CBD), inhibits breast cancer metastasis.
Dr. McAllister earned his Bachelor’s Degree in Biology and his doctoral degree in Pharmacology and Toxicology from the Medical College of Virginia Commonwealth University.
His doctoral research focused on the interactions of cannabinoids with their endogenous receptors. He completed postdoctoral training at the Forbes Norris Amyotrophic Lateral Sclerosis Research Centre, before joining CPMCRI in 1999.
“This compound offers the hope of a non-toxic therapy that could achieve the same results without any of the painful side effects.” – Dr. Sean McAllister.
Cannabis breast cancer treatment can also provide a variety of other benefits in the treatment of cancer, including the prevention of nausea and vomiting associated with standard chemotherapeutic treatments and reduction of cancer-associated pain.
Research also shows that, when combined with conventional cancer treatments, cannabinoids are able to induce a synergistic action against cancer and tumour cells, suggesting that the combination of conventional and cannabinoid-based treatments may more powerful than the administration of either treatment alone.
SCIENTIFIC RESEARCH ON THE EFFECTS OF CANNABINOIDS ON BREAST CANCER
This has so far been limited to pre-clinical trials involving cell cultures and animal models.
Researchers believe that further pre-clinical trials are necessary to identify which patient population is the most appropriate for cannabis breast cancer treatment and which cannabinoids specifically present the best therapeutic option for patients before trials can advance to the clinical stage.
Until these factors are established, it is unlikely that oncologists will be willing to prescribe cannabinoid-based medicine for the treatment of breast cancer, despite the fact that research authors continue to assert the need for health professionals to be aware of cannabinoid research. Susan Weiss Behrend is an advanced practice oncology nurse. She has functioned as a clinical nurse specialist in the areas of medical and radiation oncology.
In a 2013 article published in the Oncology Nursing Forum, associate editor Susan Weiss Behrend concluded:
“Cannabinoids have demonstrated anti tumour activity in pre-clinical breast cancer models. Practicing oncology professionals need to be aware of the clinical potential of these agents” – Susan Weiss Behrend.
According to doctors and patients we have worked closely with over the past decade, breast cancer tumours can be effectively treated with a cannabis breast cancer protocol.
However, specialists in this field offer a word of caution, the ratios of the cannabinoids THC and CBD must be matched to the classification of breast cancer-with certain types of breast cancer, namely those that are oestrogen-positive, the tumour will actually grow if too much THC is used.
CANCERS THAT INVOLVE OESTROGEN
These types of cancer may actually spread in response to large amounts of THC.
Patients with ER+ or triple-positive breast cancer do better with lower ratios of THC to CBD—a ratio 1:1 to 1:4 is preferable, this is according to doctors, patients and also specialists from Complutense University in Madrid that we have worked with and spoken to.
(HER2 or ErbB2) is a protein that is over-copied by certain types of breast cancer.
HER2-positive cancers spread more rapidly than other types of cancer. Triple negative breast cancers do not have oestrogen or progesterone receptors and don’t show overproduction of HER2.
Triple-negative breast cancers spread aggressively because they don’t respond to hormones or drugs that target HER2, but chemotherapy is an option. These types of breast cancer are ER+ and PR+, and they have too much HER2 production. They can be treated with hormones, HER2 drugs, and chemo.
Research has shown that PR+, HER2-positive, and triple-negative breast cancers can be effectively halted with cannabis breast cancer treatment.
Cannabinoid receptors are over expressed in the tumours of particular cancers, such as those of the breast, liver, lungs, and prostate. Cannabinoids from cannabis bind with these receptors and either switch off the cell’s ability to divide and replicate or simply kill it (apoptosis).
In this manner, full spectrum cannabis oils containing both cannabinoids (CBD and THC) can work in tandem with the body’s endocannabinoid system to induce cancer cell death, inhibit cell growth, or prevent the metastasis (spread) of cancer cells. In addition, unlike chemotherapy, cannabis breast cancer treatment can prevent healthy cell damage.
FULL SPECTRUM OIL & CANNABIS BREAST CANCER TREATMENT
Cancers that involve estrogen may actually spread in response to large amounts of THC.
There is a significant role for THC in cannabis breast cancer treatments, studies have suggested that different cannabinoids will fight different forms of breast cancer.
THC has been shown to induce apoptosis in ErbB2–positive breast cancer cells and inhibits tumour growth in animal models. CBD is known to work at the genetic level, blocking expression of the ID-1 gene to inhibit breast cancer metastasis.
However, the ratios of THC and CBD must be matched to the classification of breast cancer, evidence suggests that with certain kinds of breast cancer, namely those that are oestrogen-positive, the tumour will actually grow if too much THC is used.
“Many with breast cancers have been helped with the addition of THC and CBD to their standard treatment plans.
It is important to communicate with your oncologist about all cannabinoids and supplements being taken as there can be potential interactions.
With simple adjustments, the synergy between cannabis, chemotherapy, and radiation is far greater than the sum of its parts.” – Mara Gordon.
Research has shown that PR+, HER2-positive, and triple-negative breast cancers can be effectively treated with cannabis. The protocols recommended for cannabis breast cancer treatment have high THC-to-CBD ratios – A ratio of around 4:1.
Cancers that involve oestrogen, however, may actually spread in response to large amounts of THC. Patients with ER+ or triple-positive breast cancer do better with cannabis breast cancer treatments containing lower ratios of THC to CBD – A ratio 1:1 to 1:4 is preferable.
FULL SPECTRUM CANNABIS OIL, NOT CBD, SAVED ME! – DEE MANI CANCER SURVIVOR
Dee Mani made headlines when she revealed to the media that she had “cured” her breast cancer using full spectrum cannabis oil (not isolate CBD).
Dee also had a lumpectomy which was the only medical intervention (image left shows scars). The British mother, 44, was diagnosed with Grade 3 Triple Negative Breast Cancer on 16th March, 2017. Dee was given the all-clear in August, 2017, claiming that her win over Cancer was due to the cannabis oil she had been treating herself with.
“My oncologist expected me to have a combination of chemotherapy and radiotherapy for 12 months. Apparently Triple Negative doesn’t respond to any anti-cancer drugs and following the lumpectomy there would still be cancer cells left over. I refused the chemotherapy and radiation, and was given the all clear on 14th August, 2017!”
Dee’s inspiring story could have been used to raise awareness of full spectrum cannabis oil and its efficacy as a breast cancer treatment. Instead, Dee’s story was misappropriated as an advert for CBD crystal isolate products!
MAMMOGRAPHY DIAGNOSIS ISSUES AND CANNABIS BREAST CANCER TREATMENT
Most women diagnosed via mammography never had a cancer problem to begin with!
Before considering drastic surgery or aggressive chemotherapy it is worth noting that a new scientific study has confirmed that: most women diagnosed with breast cancer via mammography, never had a cancer problem to begin with.
Almost 93% of early detection has no benefit to the patient whatsoever, according to a new study published in the New England Journal of Medicine.
Study co-author Dr. Gilbert Welch states, “We found that the introduction of screening has been associated with about 1.5 million additional women receiving a diagnosis of early stage breast cancer.”
Dr. Welch’s team discovered, there was virtually no reduction in late-stage breast cancer from these early diagnosis, meaning that many women who were told they had breast cancer after a mammogram were being mislead.
Most women diagnosed agree to start treatment immediately, this consists of injections of expensive and highly toxic chemicals which oncologist prescribe to the very same patients they have incorrectly diagnosed.
Furthermore, The U.S. Preventive Services Task Force recently advised that most women don’t need mammograms as early or often as previously believed.
However, it is important to note that cannabis breast cancer treatment has no side effects, is beneficial to our immune system and can safely taken as a precautionary measure regardless of diagnosis.
THE LINK BETWEEN ALCOHOL AND BREAST CANCER LARGELY IGNORED BY WOMEN MOST AT RISK OF DEVELOPING THE POTENTIALLY DEADLY DISEASE
Middle-aged women most at risk of developing breast cancer are not getting the message about the proven link between alcohol and breast cancer, new research suggests.
Study lead author Dr Emma Miller states that there is a low level of awareness about the established link between alcohol and breast cancer, and some confusion about the risk given the community perception that not all drinkers get breast cancer.
Dr Miller added: ‘We all want to hear good news about drinking, such as small amounts of red wine may be good for cardiovascular disease, which is a message that’s promoted by the alcohol industry.
‘In contrast, information that alcohol is linked to breast cancer is actively suppressed by the industry presumably in order to build the female customer base.
‘Our research shows that while more middle aged women are drinking, there are ways of getting the right messages through by focusing on issues important to them.
Most cases develop in women over the age of 50 but younger women are sometimes affected. It is advisable for most of us, not just women, to seriously consider how alcohol use can affect our health and well being. It is not just the proven link between alcohol use and cancer that is of concern.
Encouragingly it is being reported that many health conscious Hollywood personalities are now promoting an alcohol free lifestyle as the new Botox, due to the aging affect alcohol has on your skin.
STEFANIE LARUE: CANNABIS TREATMENT & BREAST CANCER SURVIVAL
In 2005, Stefanie discovered a lump in one of her breasts, she was only 30 years old.
Initially she was misdiagnosed by three different doctors and was told that she was too young for breast cancer.
Stefanie was treated with prescribed antibiotics, which failed to have any effect, so by the time she was tested and correctly diagnosed, the cancer had spread to her bones.
Doctors diagnosed her with Stage 4 Metastatic Breast Cancer, meaning the cancer had spread beyond the breast to other organs in the body. There is no stage 5. The prognosis she was given predicted one year to live, at most.
With help from her oncologist at UCLA, Stefanie learned to make changes to her diet, use natural supplements and work on personal fitness; all of which are integrative and complimentary treatments alongside chemotherapy. After six chemotherapy treatments, Stefanie had surgery to remove the cancer which removed all of her breast tissue.
n 2013 Stefanie had a Video-Assisted Thoracoscopic Surgery (VATS) and the results indicated her third re occurrence of cancer. The chemo sensitivity testing concluded there were five lines of chemo treatments that could work on the tumours.
“I did my homework. I researched as much as I could. I watched. I listened. I read. I contacted. I prayed. Most of all, I believed. I weighed my options, which were essentially chemotherapy or cannabis oil, and I decided to take the natural route this time.”
Stefanie declined and decided to complete an alternative 90 day concentrated cannabis oil treatment. It was successful and she now only takes a maintenance dose of 0.5 grams of cannabis oil per day.
“Cannabis oil killed all of the tumours in my body. My monthly lab and quarterly scan results are proof that the cannabis oil treatment worked.”
Her last scan in December of 2014 showed no signs of cancerous tumours. Her doctor, who had previously been sceptical, now credits these “alternative” treatments as the reason for her speedy recovery.
FLORIDA WOMAN TREATED BREAST CANCER WITH CANNABIS
Tammy’s remarkable journey to recovery.
Tammy Levent is currently using cannabis oil to keep her cancer in remission. During May of 2015, Tammy became diagnosed with malignant breast cancer.
Although the disease quickly began to spread, she refused to seek traditional treatments.
“They thought I was absolutely insane. They’re like it’s not going work, you can’t be doing this, and I was like it’s my body, and this is what I want to do.”
Despite going against doctor’s orders by relying on strictly cannabis oil, she is now cancer free, and doctors are now interested as to how cannabis is keeping the disease at bay. Tammy Levent’s bloodwork tumour markers are still all zero and oncologists are at a loss to explain it.
BREAST CANCER ALSO OCCURS IN MEN
Breast cancer is not gender specific.
An early diagnosis helped save Stephen Sala, who opted for conventional treatment without cannabis oil. In August 2016 he found a small lump on the right side of his chest. His doctor scheduled an ultrasound and a mammogram the same day, followed by a needle biopsy a week later. The results showed breast cancer. He was 41.
“I experienced a number of awkward situations. Almost all mammography offices are in women’s health care centres, with no consideration for men. I was given forms that asked me when my last period was and how many children I had given birth to.”
EXPERTS ADVISE MONTHLY SELF-EXAMINATIONS FOR BREAST CANCER
Women are putting their health at risk by failing to check their breasts for signs of cancer.
Experts recommend women carry out self-checks every month to feel for lumps or changes that could be a sign of the disease.
Yet one in four women admitted they had either never carried out their own examinations or could not remember the last time they had, a survey found.
Almost four in ten said they would delay going to see a doctor for medical help if faced with a symptom because of embarrassment or difficulties getting an appointment, according to the survey by private health firms BUPA and HCA Healthcare.
Last night charities described the findings as ‘worrying’, adding that early diagnosis was key to surviving breast cancer.
Eluned Hughes, of Breast Cancer Now, said: ‘The earlier breast cancer is detected, the more likely treatment is to be successful. It’s vital that all women are supported to know the signs and symptoms to look out for, like a lump, changes to the nipple, or dimpled skin and to visit their doctor straight away if they’re concerned about any changes to their breasts.’
Latest figures show 90 per cent of women diagnosed can now expect to survive for a year unless they are diagnosed at stage 4, when the survival rate drops considerably to 66 per cent.
Yet 23% of the 2,000 women surveyed said they would wait for up to two weeks and one in ten would wait for up to a month before seeing a doctor.
Dr Fran Woodard, of Macmillan Cancer Support, said: ‘Early diagnosis is crucial to ensuring that you can not only survive cancer, but live as full a life as possible. It’s worrying to see such large numbers of women would delay having symptoms checked and if anybody is worried, they should consult their doctor as soon as possible.’
TWELVE SIGNS OF BREAST CANCER
Warning signs to look out for in the fight against breast cancer.
Thick mass: A sudden thickening of the breast tissue can be a sign of a serious underlying condition such as lobular or inflammatory breast cancer
Indentation: Some people notice a dip, or dent, in the breast. This can be because the cancer is tethered to the breast tissue and so pulls it inwards
Skin erosion: In rare cases cancer that is growing under the skin can break through and create a wound
Heat or redness: If the breast feels warm to touch or there’s redness one-third of the breast, it can be a sign of inflammatory breast cancer
New fluid: Spontaneous nipple discharge on one side, which may be blood stained, brown or clear, might mean there is something in the breast that is causing irritation
Dimpling: Dimpled skin is a common sign of inflammatory breast cancer
Bump: A localised swelling, bulge or bump on the breast should always be investigated
Growing vein: Changes such as dilated veins can be a sign that cancer is blocking a blood vessel
Retracted nipple: Developing an inverted nipple – i.e. not being born with one – which can’t be drawn out, may suggest a lump behind the nipple is pulling it in.
New shape or size: Any change in shape or size not associated with the menstrual cycle should be investigated
Orange peel skin: Skin that has ridges or appears pitted, like the skin of an orange, can be caused by a build up of fluid in the breast
Invisible lump: Even though there are many other symptoms, it’s crucial to always check your breasts for lumps. A cancerous lump often feels hard and immovable like a lemon seed.